A ninth RCT directly comparing amiodarone with dronedarone was discussed but not included in the pooled analyses. Compared against placebo, amiodarone was associated with a significant reduction in recurrent atrial fibrillation (OR 0.
12, 95 CI 0. 08 to 0. 19), but dronedarone was not. Dronedarone is an option if a patient cannot tolerate amiodarone or has an underlying condition such as pulmonary or thyroid disease that is a contraindication to amiodarone. Dronedarone is contraindicated in patients with significant left ventricular dysfunction or heart failure with recent decompensation.
Dronedarone is a benzofuran analog of amiodarone, developed by modifying the structure of amiodarone. Dronedarone appears to share its pharmacological actions, but lacks the iodine component that is largely responsible for Compare Amiodarone vs.
Dronedarone, which is better for uses like: Arrythmia and Recurrent Atrial Fibrillation. Compare headtohead ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Dronedarone 35 over Amiodarone 2. 45 in overall satisfaction. Amiodarone effectively maintains sinus rhythm in patients with atrial fibrillation, and although dronedarone is less effective it has a better safety profile. The choice of antiarrhythmic drug (or Dronedarone Two major obstacles which dampen the clinical efficacy of any antiarrhythmic drug are its paradoxical proarrhythmic Comparison of amiodarone and dronedarone DURHAM, NORTH CAROLINA.
Amiodarone (Cordarone) is the most effective antiarrhythmic drug on the market today, although a recent trial found that its efficacy in keeping atrial fibrillation patients afibfree for a year is only 34.