Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on 'small' chemical compounds. 15 rows USA Home Product Directory Chemical Synthesis Chemical Biology Diastereo and Enantioselective Synthesis of, Diaminobutyric Acid Derivatives via CuCatalyzed Asymmetric Michael Reaction Search results for Diaminobutyric acid at SigmaAldrich.
Compare Products: Select up to 4 products. Please select more than one item to compare In the present work, we report the synthesis and the characterization of a new chiral nucleoaminoacid, in which a diaminobutyric moiety is connected to the DNA nucleobase by an amidic bond, and its oligomerization to give the corresponding nucleopeptide.
In the present work, we report the synthesis and the characterization of a new chiral nucleoaminoacid, in which a diaminobutyric moiety is connected to the DNA nucleobase by an amidic bond, and Excess acid, which was used for the isolation however, left an unknown residue in the alcohol, possibly as the ethyl ester of the dihydrochloride.
The 2, 4diaminobutyric acid was characterized by preparation of the dipicrate. 2, 4Diaminobutyric acid is a nonphysiological, cationic amino acid analogue that is transported into cells by System A with potent antitumoral activity in vitro against human glioma cells, the result of the pronounced concentrated uptake of DAB in glioma cells to the extent that a cellular lysis could occur due to osmotic reasons.
(PMID: ). The ring opening of butyrolactone with 1 mole of potassium phthalimide and the hydrolysis of the intermediate product gave 4aminobutyric acid with an excellent yield. The condensation of 1 mole of potassium phthalimide with 2bromo4butyrolactone gave a 2phthalimidolactone which can also be opened by treatment with a second Following the synthesis, the acidic solution was passed through Dowex3 ionexchange column twice to remove sulphuric acid and any unreacted glutamic acid completely.
The eluate was then concentrated to obtain the 2, 4diaminobutyric acid or excess hydrochloric acid was added to ensure obtaining the dihydrochloride salt. Although we were unable to show marked elevations of blood ammonia concentration after treatment with l2, 4diaminobutyric acid, these results are interpreted to mean that ammonia utilization (urea synthesis) in liver is inhibited by l2, 4diaminobutyric acid and that at least part of the neurotoxicity is due to a prolonged slight increase in body THE SYNTHESIS AND CYCLIZATION OF 2, 4DIAMINOBUTYRIC ACID INTRODUCTION Historical Much of the interest in the investigation of 2, 4diaminobutyric acid stems from its discovery, in, as the major constituent Synthesis of 2, 4diaminobutyric acid by Carter et al.
(8). A synthetic route to the four stereo isomers of, diaminobutyric acid (, A2bu) has been developed. The L threo, D threo, L erythro and D